This expression refers to someone who has broken a fundamental agreement or messed with something highly personal and off-limits to another person. (The pesebre is a traditional Christmas nativity scene, which is considered a sacred and fragile display in Venezuelan homes.)
I fell in love with your sister... Dude, you messed with the corotos del pesebre. / You scratched your mother's car! You have messed with the corotos del pesebre!
Used to tell someone they messed up, blew it, or made a mistake. It indicates that the person did something that was not the way to go or handled a situation incorrectly.
You messed up (La dañaste) because you did not listen to me.
To break or wreck a device or appliance, especially by roughly handling or twisting its moving parts until they snap or malfunction (derived from cocote, a regional term for neck).
Look at that damn kid! Because he kept messing with it, he descocoto that fan! Now it does not even spin anymore!