To screw someone over, to ruin, or to cause severe damage with malicious intent. (In Mexico, this is a very common and vulgar verb used to express causing significant harm to others).
In Mexico, La Chingada is a mythical mother figure representing the violated or woman who has been screwed, distinct from the idealized mother celebrated on Mother's Day (May 10 is the traditional holiday in Mexico). The verb chingar implies a corrosive or shameful action. Its origins may be Aztec, possibly derived from words for seeds or fermented dregs. In various Spanish-speaking countries, the root relates to alcohol, such as dregs in a glass, taverns, or heavy drinking. It also describes failure, like a firework that does not explode or a business that falls through.
FRAUD: They cheated me (Me chingaron). THEFT: They stole it from me (Me lo chingaron). IGNORANCE: Who the hell knows (Sepa la chingada). THREAT: I am going to mess you up (Te voy a chingar). BRAGGING: I am a total badass (Soy el más chingon). DISTANCE: Way out in the middle of nowhere (Hasta la chingada). CONTEMPT: You are worth shit (Vales para pura chingada). JEALOUSY: Who the hell were you with (Con quién chingados estabas)? DISSATISFACTION: This is bullshit (Son chingaderas)! They are really pushing it (Ya ni la chingan). REQUEST: Go to hell (Vete a la chingada). EPITHET: A passive-aggressive pest (Chingaquedito). HOSTILITY: And who the hell are you (Y tú quién chingados eres)? FRUSTRATION: Man, you are annoying (Ah que bien chingas)! TERMINAL: He is done for (Ese ya chingó a su madre). UNCERTAINTY: They are not going to screw us, are they (Y no nos irán a chingar)? ORDER: Get him (chingatelo). CERTAINTY: We are screwed (Ya nos chingaron). WARNING: Keep it up and you are dead meat (Síguele y te va a cargar la chingada). INCOMPETENCE: I do not know what the hell to do (No sé que chingados hacer). DISCRETION: Damn (Chingao). ANGER: He can go screw himself (Que vaya y rechingue a su madre). COMPASSION: They gave him a hell of a beating (Que fea chinga le metieron). TRIUMPHALISM: I did it (Ya chingué). DEFEATISM: I am screwed (Me chingué).